The Number of the Beast is 666 by William Blake (1805)

Image: Martin Luther from the workshop of Lucas Cranach the Elder

Martin Luther, in his break from the Catholic Church, came to reluctantly believe that Pope Leo X was the Anti-Christ. Though for much of his early life he was not greatly concerned with the book of revelations, later in life he sought to use its symbolism to determine when the world would end. 

La bête à sept têtes et à dix cornes by Jean Duvet (16th century)

Last Judgement by Hieronymus Bosch (1516)

The Seven-Headed Dragon and the Woman Clothed in the Sun by Hans Brosamer (16th century)

Jena Codex, The Beast of the Apocalypse: Pope as the Anti-christ (c. 1500)

The Four Avenging Angels of Euphrates by Albrecht Durer

Triptych of the Last Judgement by Hieronymus Bosch (c. 1500)

The Four Horsemen by Albrecht Durer (1498)

The Beast with Two Horns Like a Lamb (Apocalypse) by Albrecht Durer (1497)

Livre de la Vigne nostre Seigneur: The death of Antichrist on Mount Olivet (c. 1450-1470)

The Last Judgment by Jan van Eyck (c. 1430)

Commentary on the Apocalypse: Men Adoring Beast with Two Horns (15th century)

Apocalypse of Angers: Assault of the City by the Seven-Headed Beast by Nicolas Bataille (c. 1373-1387)

Apocalypse (c. 1250-1260, English)